White paper on continuous bioprocessing

By William Chin, PhD, Scientific Coordinator, EUCRAF

Greater demands on the development of biologics with emphasis on higher titers, greater efficiency and higher utilization has called for continuous bioprocessing in the manufacturing of biologics. As a result of this, there are significant activities both from the industrial and academic researchers in the development of continuous bioprocessing systems. Among the advantages of continuous manufacturing include:

  • Sustained operation with consistent product quality
  • Reduced equipment size
  • High-volumetric productivity
  • Streamlined process flow
  • Low-process cycle times
  • Reduced capital and operating cost

However, no technology comes without its intrinsic disadvantages. The objective of this article is to provide a consensus of the opportunities, technical needs, and strategic directions for continuous bioprocessing.

Source: 21 Nov 2014 issue of J Pharm Sci